Fragments 2019

7th RSC-BMCS Fragment-based Drug Discovery meeting

Sunday to Tuesday, 24th to 26th March 2019

at Churchill College, Cambridge, UK


Click image to the top left for flier download.


Registration is not yet open


Downloads and Links

First announcement

Abstract template - closing date for poster submissions is 10th February 2019


Travel information and directions to Churchill College

RSC website


The aim of the 7th RSC-BMCS Fragment-based Drug Discovery meeting will be to continue the focus on case studies in Fragment-based Drug Discovery that have delivered compounds to late stage medicinal chemistry, preclinical or clinical programmes. The Fragment series was started in 2007 and continues with the theme, having over three-quarters of the presentations focused on case studies. The conference will include successful examples from all types of fragment-based approaches, including high concentration, NMR, SPR and X-ray screening.

Who should attend

This conference is suitable for scientists including all chemists as well as other important disciplines including biophysics, structural biology, etc. This international meeting attracts delegates from the UK, several mainland European countries, as well as from the USA, Japan, China and South Korea.

Pre-conference Workshop
A pre-conference workshop is planned with some new material to offer those new to the area of FALG/FBLG an introduction into the fundamental principles governing fragment-based drug discovery approaches. A series of four short presentations with opportunities for discussions is planned. The pre-conference workshop will only be held if sufficient interest is evident, and will be offered free-of-charge to conference attendees.

Call for Posters
Selected student speakers will be invited to present at the flash presentation session prior to the poster session.  Please download an abstract template here, and note the closing date of 10th February 2019.

Confirmed Speakers

Discovery of chemical probes for new target families using XChem and poised fragments

Paul Brennan, Structural Genomics Consortium, UK

Tractability assessment and hit ID using photoreactive fragments (PhABits)

Jacob Bush, GlaxoSmithKline, UK

Presentation title to be confirmed

Rob Cooke, Heptares, UK


Presentation title to be confirmed

Benjamin Cravatt, The Scripps Research Institute, US

Presentation title to be confirmed

Harren Jhoti, Astex Pharmaceuticals, UK

Fragment-based approaches to covalent inhibitors

György M Keserű, Hungary Academy of Sciences, HU

Nanomolar KRAS inhibitors using fragments, NMR and Xray

Dirk Kessler, Boehringer Ingelheim, AT

Presentation title to be confirmed

Christian Ottmann, University of Eindhoven, NL

Presentation title to be confirmed

Payal Seth, Merck, US


Kinetic fragment discovery, fragment recombination, and a cure for the common cold
Edward Tate, Imperial College London, UK


Learnings from fragment based lead generation for RORg

Yafeng Xue, AstraZeneca, SE


Bursaries and Sponsorship
Bursaries will be available based on sponsorship of the event. If you wish to sponsor students to expand their knowledge in this area please contact the secretariat for further information.

We are grateful to our sponsors for their support of this event.

This meeting is part-sponsored by





Exhibition Opportunities
Those companies wishing to have a trade stand should apply early to avoid disappointment as these are limited.

Registration and Fees
Registration is not yet open.

Registration fees will include the Sunday afternoon workshop, Sunday buffet dinner, and Monday evening conference dinner (opt in required).

* Student is undergraduate or post-graduate, not post-doc, and does not apply to students in paid employment.
Member is paid-up member of the RSC.

Cancellation Policy
In the event of cancellation before xxth February 2019, 80% of the fee paid will be refunded. Cancellations must be received in writing.  Refunds will not be possible after that date although substitutions are possible at any time.

Accommodation fees will only be refunded (in line with the policy above) if the room can be resold.

In the unlikely event of cancellation of the meeting, fees paid will be refunded in full. Registration acknowledgements will be sent within two weeks.
B&B accommodation at Churchill College in an en-suite bedroom will be available to book at the time of registration for both Sunday and Monday.

Conference Dinner
The conference dinner on Monday will be held in the Old Courts Main Hall at Gonville and Caius College, and attendance is included in the registration fee.

Venue and Travel
Address:  Churchill College, Storey's Way, Cambridge CB3 0DS.

Travel Overview:  Churchill College is a 15-minute walk from the centre of Cambridge. Travel to Cambridge is convenient by rail as well as by road. 


Rail and Air: The College is 2.7 miles from Cambridge railway station, and 32 miles from Stansted airport.  


Car: There is ample free parking on site along Churchill Road (the College's private road) in the main car park at the end of that road, and in the staff car park (if available). A clearly-sign posted grassed area may also be available. Visitor parking permits are not required.


Directions: Please follow this link, and here is a site plan of Churchill College

Register an interest

To register an interest and be notified when registration has opened, please send an e-mail to the Secretariat, Maggi Churchouse.

Organising Committee

John Barker Evotec
Mike Hann GlaxoSmithKline
Samantha Hughes AstraZeneca
Darryl McConnell Boehringer Ingelheim
Thorsten Nowak C4X Discovery
Gordon Saxty (chair) Fidelta
Alison Woolford Astex Pharmaceuticals

Registration is not yet open