Fragments 2019

7th RSC-BMCS Fragment-based Drug Discovery meeting

Sunday to Tuesday, 24th to 26th March 2019

at Churchill College, Cambridge, UK

 

Click image to the top left for flier download.

 

Registration is open

 

Downloads and Links

Online registration - for payment by card - to be made available

Registration form - for payment by bank transfer

 

Second announcement

First announcement

Abstract template - closing date for poster submissions is 1st February 2019

Bursary application form - closing date is 1st February 2019

 

Travel information and directions to Churchill College

RSC website

Synopsis

The aim of the 7th RSC-BMCS Fragment-based Drug Discovery meeting will be to continue the focus on case studies in Fragment-based Drug Discovery that have delivered compounds to late stage medicinal chemistry, preclinical or clinical programmes. The Fragment series was started in 2007 and continues with the theme, having over three-quarters of the presentations focused on case studies. The conference will include successful examples from all types of fragment-based approaches, including high concentration, NMR, SPR and X-ray screening.

Who should attend

This conference is suitable for scientists including all chemists as well as other important disciplines including biophysics, structural biology, etc. This international meeting attracts delegates from the UK, several mainland European countries, as well as from the USA, Japan, China and South Korea.

Pre-conference Workshop
We are pleased to announce that we have completely changed the pre-conference workshop for this event. It will contain new materials provided by new speakers compared with previous years.   The pre-conference workshop is intended for those new to the area of FALG/FBLG an introduction into the fundamental principles governing fragment-based drug discovery approaches.

 

A series of four short presentations with opportunities for discussions is planned. The pre-conference workshop will only be held if sufficient interest is evident, and will be offered free-of-charge to conference attendees.

Call for Posters
Selected student speakers will be invited to present at the flash presentation session prior to the poster session.  Please download an abstract template here, and note the closing date of 1st February 2019.

Programme - draft

 

Sunday, 24th March

Training Course

Session chair

15.00

Introduction to FBDD

Roderick Hubbard, University of York and Vernalis, UK

15.40

X-ray crystallography: an essential tool in Fragment Discovery but how to know its limitations

John Barker, Evotec, UK

16.15

Refreshments

16.45

Which fragment hit do I use?

Alison Woolford, Astex Pharmaceuticals, UK

17.20

Why fragments are the best training ground for our next generation of drug hunters

Darryl McConnell, Boehringer Ingelheim, Austria

18.00

Close

 

Monday, 25th March

10.20

Opening remarks

10.30

The Lundbeck approach to FBDD in the CNS drug space: from weak fragments to the PDE1 inhibitor development candidate

Mauro Marigo, Lundbeck, Denmark

11.15

Enabling drug discovery against the Bcl-2 family of proteins - from fragments to clinical candidates
Roderick Hubbard, University of York and Vernalis, UK, and
Andras Kotschy, Servier Research Institute of Medicinal Chemistry, Hungary

12.00Flash poster presentations
12.30Lunch, poster session, exhibition
13.30

Learnings from fragment based lead generation for RORg

Yafeng Xue, AstraZeneca, Sweden

14.15Fragment based lead discovery at Merck
Payal Sheth, Merck and Co, USA
15.00Refreshments, exhibition and posters
15.30

Fragment-based discovery of JAK1 inhibitors with excellent subtype selectivity

Andreas Ritzén, LEO Pharma, Denmark

16.15

Twenty years of thinking small
Harren Jhoti, Astex Pharmaceuticals, UK

17.00

Close

 

18.40

Walk to conference dinner

19.00Reception and conference dinner at Gonville and Caius College

 

Tuesday, 26th March

 Session chairMike Hann, GlaxoSmithKline, UK

09.00

Fragment-based approaches to covalent inhibitors
György M Keserű, Hungarian Academy of Sciences, Hungary

09.45

Fragment-based stabilization of 14-3-3 Protein-Protein Interactions
Christian Ottman, Eindhoven University of Technology, The Netherlands

10.30

Refreshments, exhibition and posters

11.00

Fragment-based discovery of chemical probes for new targets
Paul Brennan, Structural Genomics Consortium, University of Oxford, UK

11.45

Activity-based proteomics – protein and ligand discovery on a global scale
Ben Cravatt, The Scripps Research Institute, USA

12.30Lunch, poster session, exhibition
13.30Kinetic fragment discovery, fragment recombination, and a cure for the common cold?
Ed Tate, Imperial College London, UK
14.15

Enabling FBDD for GPCRs with protein engineering and biophysics

Rob Cooke, Sosei Heptares, UK

15.00

Refreshments, exhibition and posters

15.30Tractability assessment and hit ID using photoreactive fragments (PhABits)
Jacob Bush, GlaxoSmithKline, UK

16.15

Nanomolar KRAS inhibitors using fragments, NMR and Xray
Dirk Kessler, Boehringer-Ingelheim, Austria

17.00

Closing remarks

Close and depart

   

Bursaries and Sponsorship
Bursaries are available based on sponsorship of the event.

Bursary applications are invited - please complete this application form and return it to the Secretariat.  The closing date is 1st February.

 

If you wish to sponsor students to expand their knowledge in this area please contact the secretariat for further information.

We are grateful to our sponsors for their support of this event.

This meeting is part-sponsored by

 

 

 

  

 

      

Exhibition Opportunities
Those companies wishing to have a trade stand should apply early to avoid disappointment as these are limited.

 

Exhibition charges are:

£750  exhibition stand space only (excludes attendees)

£146  trade stand staff rate (no access to the technical sessions, conference dinner excluded)

£72    conference dinner for trade stand staff

Full delegate rates as detailed below

 

Delegate pack inserts may be booked at £275.

 

More details of exhibition stands will be available shortly.

 

Registration and Fees
Online registration - for payment by card

Registration form - for payment by bank transfer

 

Registration fees include the Sunday afternoon workshop, Sunday buffet dinner, and Monday evening conference dinner (opt in required).

 

Early rates for payments received by 21st January
£300 RSC member
£380 non-member

£155 RSC student* member

£195 student* non-member

Standard rates for payments received between 22nd January and 22nd February
£360 RSC member
£450 non-member

£185 RSC student* member

£230 student* non-member

Late rate for payments received from 23rd February onwards
£55   late payment fee to be added to all the above standard rates
 

* Student is undergraduate or post-graduate, not post-doc, and does not apply to students in paid employment.
Member is paid-up member of the RSC

 

£78   one night's B&B accommodation in an en suite room at Churchill College (Sunday and Monday available)

 

Cancellation Policy
In the event of cancellation before 9th March 2019, 80% of the fee paid will be refunded. Cancellations must be received in writing.  Refunds will not be possible after that date although substitutions are possible at any time.

Accommodation fees will only be refunded (in line with the policy above) if the room can be resold.

In the unlikely event of cancellation of the meeting, fees paid will be refunded in full.  Registration acknowledgements will be sent within two weeks.
Accommodation
B&B accommodation at Churchill College in an en-suite bedroom are available to book at the time of registration for both Sunday and Monday, charged at £78 per night.

Conference Dinner
The conference dinner on Monday will be held in the Old Courts Main Hall at Gonville and Caius College, and attendance is included in the registration fee - opt in required.

Venue and Travel
Address:  Churchill College, Storey's Way, Cambridge CB3 0DS.

Travel Overview:  Churchill College is a 15-minute walk from the centre of Cambridge. Travel to Cambridge is convenient by rail as well as by road. 

 

Rail and Air: The College is 2.7 miles from Cambridge railway station, and 32 miles from Stansted airport.  

 

Car: There is ample free parking on site along Churchill Road (the College's private road) in the main car park at the end of that road, and in the staff car park (if available). A clearly-sign posted grassed area may also be available. Visitor parking permits are not required.

 

Directions: Please follow this link, and here is a site plan of Churchill College

Organising Committee

John Barker Evotec
Mike Hann GlaxoSmithKline
Samantha Hughes AstraZeneca
Darryl McConnell Boehringer Ingelheim
Thorsten Nowak C4X Discovery
Gordon Saxty (chair) Fidelta
Alison Woolford Astex Pharmaceuticals

Registration is open