29th symposium on

Medicinal Chemistry in Eastern England


Thursday 26th April 2018

The Fielder Centre, Hatfield, Hertfordshire, UK



Registration is open


Downloads and Links

Online registration - for payment by card

Registration form - for payment by bank transfer or cheque

Second announcement and call for posters

First announcement and call for papers

Directions to the Fielder Centre
Accommodation suggestions
RSC website


The Symposium on Medicinal Chemistry in Eastern England, known colloquially as the "Hatfield MedChem" meeting, is a highly successful, long-standing, one-day meeting which runs annually. The scientific programme will comprise presentations showcasing medicinal chemistry case studies from tools to candidates, across a range of modalities, therapeutic areas and target classes, as well as covering more general topics from the forefront of drug discovery of relevance to medicinal chemists. The meeting aims to be informal and interactive and the event will offer excellent scientific and networking opportunities for all those working in medicinal chemistry and drug discovery.


Call for Papers
The Organising Committee were inviting abstract submissions for poster presentation. The closing date for submission was 23rd February 2018.


Registration and Bursaries
Online registration - for payment by card

Registration form - for payment by bank transfer or cheque

Registration is open and fees are:

£100   RSC member

£135   Non-member

  £55   RSC student* member
Free   Retired RSC member (limited places)
£205   Exhibition stand space only -
sorry, fully booked
  £65   Trade stand staff (no access to technical sessions) 
* Student is undergraduate or post-graduate, not post-doc

Some student bursaries were available, and the closing date for application was 2nd April. 


Programme - provisional



Registration, refreshments and exhibition


Welcome and introduction

Nicole Hamblin, Charles River, UK


Session chair:  Samantha Hughes, AstraZeneca


Discovery of Padsevonil for the treatment of drug-resistant epilepsy

Laurent Provins, UCB, Belgium


Development of potent and selective ATM inhibitors for proof of concept studies in Huntington’s disease

Perla Breccia, Charles River Discovery, UK


Discovery and characterisation of novel indoleamine 2,3-dioxygenase inhibitors

Dean Boyall, Vertex Pharmaceuticals, UK


Refreshments and exhibition


The development of hypoxia activated pro-drugs of the clinically approved KDAC inhibitor Panobinostat

Stuart Conway, University of Oxford, UK


A song of 6p – genuine diversity in short order: development of facile 2+2+2 cyclotrimerisation chemistry and applications in drug discovery

Simon Peace, GlaxoSmithKline, UK


Lunch and exhibition


Session ChairSimon Ward, Medicines Discovery Institute, Cardiff University


Capps Green Zomaya Award presentation lecture

Discovery of GDC-0853: a highly potent, selective, and non-covalent Btk inhibitor

James Crawford, Genentech, USA


From pan-kinase promiscuity to selective protein degradation using PROTACs

Christopher Tinworth, GlaxoSmithKline, UK


Scaling de novo design, from single target to disease portfolio

Willem van Hoorn, ExScientia, UK


Refreshments and exhibition


Discovery of a selective partial agonist muscarinic M1 receptor occupancy/PET tracer

Paul Goldsmith, Lilly, UK


Non-cleavable pyrrolobenzodiazepine antibody-drug conjugates

Stephen J Gregson, Spirogen, UK


ASTX660, the first fragment-derived IAP antagonist in the clinic

Ben Cons, Astex Pharmaceuticals, UK


Concluding remarks




A relevant trade exhibition will add value to the symposium.  


Exhibition stand space only will be priced at £205 excluding any attendees. The exhibition will be held in the same room as the catering (refreshments and lunch) and posters, and the exhibition package will include:
- chair and table, measuring 120 cm wide x 70 cm deep.
- electrical access and wi-fi access.
- the option to include a promotional page for your organisation in the delegate handbook

The exhibition consistently sells out, so early booking will be recommended.  Sorry, fully booked.


Venue and Travel
The symposium will be held in the Lecture Theatre at the Fielder Centre, Hatfield Business Park, Hatfield Avenue, Hatfield AL10 9TP.  Directional information may be found here, and this is a link to the venue's website.

The Fielder Centre can be reached easily by road, rail or air:
- Just off junction 4 of the A1(M)
- 5 minutes from the M25 motorway
- 10 minutes from the M1 motorway
- 30 minutes from London Luton and Stansted Airports
- 25 minute rail journey from London Kings Cross


Cancellation Policy
For cancellations received in writing by the Secretariat, 80% of the fee paid will be refunded for notifications received before 13th April. No refunds will be made for cancellations received from 14th April onwards, although substitutions are possible at any time. In the unlikely event of our cancelling the event, we will refund the registration fees paid in full.


Sponsors are encouraged to support this popular event.



We are grateful to EFMC, MedChemNet and COMS

for supporting this event




Organising Committee
Seb Campos, GlaxoSmithKline

Adrian Hall, UCB
Nicole Hamblin, Charles River (chair)

Secretariat Contact
Maggi Churchouse, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK
Telephone: +44 (0)1359 221004
E-mail:  maggi@maggichurchouseevents.co.uk


Registration is open