4th RSC / DMDG / DMG

New Perspectives in DMPK

 

 

Monday-Tuesday, 21st-22nd May 2018

Royal Society of Chemistry at Burlington House, London, UK

 

 

Registration is closed

  

Downloads and Links
Second announcement and call for posters

First announcement and call for papers


Directions to the venue

Accommodation suggestions
RSC website

DMDG website

 

Synopsis
This meeting provided a forum for the exchange of ideas between principal members of the DMPK (Drug Metabolism and Pharmacokinetics) research community. Keynote talks from thought leaders in industry and academia provided global perspectives on how DMPK can bring value to the process on informing drug discovery and development. A range of ‘hot topics’ were discussed, with a key theme being the central importance of understanding and harnessing underpinning chemical concepts. The emphasis was on building dialogue between participants, who ranged from experienced project/laboratory leaders to early-career researchers. There was a balanced mix of oral and poster presentations, interactive Q&A sessions and networking opportunities throughout.

 

Who should attend
Medicinal chemists, drug discovery scientists, pharmacologists, toxicologists, DMPK scientists – from academia, industry, and third sector institutions.

 

Call for Posters
Abstracts were invited for poster presentation, and the closing date was 23rd April.   Some authors were invited to deliver short  flash oral presentations (five minutes each).
 

 

Programme  Where presentation titles are highlighted thus, you may download a .pdf of the presentation slides.

Monday, 21st May

11.30

Registration and lunch

12.30

Welcome
Toby Athersuch, Imperial College London, UK
on behalf of the Joint Organising Committee (RSC-BMCS, DMDG, DMG)

12.40

Keynote presentation - The renaissance of biocatalysis in DMPK: lead diversification and metabolite synthesis

Douglas Spracklin, Pfizer, USA

 

 

Session 1 - Recent Highlights in DMPK Research

Session chair: Muireann Coen, AstraZeneca / DMG

13.30

Avoiding collateral damage from magic bullets

Ted Parton, Mekinopsis Ltd, UK

14.10

Building on the success of osimertinib - achieving CNS exposure in oncology drug discovery
Nicola Colclough, AstraZeneca, UK

14.50

Understanding drug bioactivation in adverse drug reactions: a chemical and molecular perspective
Xiaoli Meng, University of Liverpool , UK

15.30

Refreshments, exhibition and posters

 

 

Session 2 - Chemistry meets Large Molecules

Session chair:  Mark Seymour, Covance / DMDG

16.00

Enzyme shielding in a soft organo-silica layer: biopharma applications

Yves Dudal, Inofea, Switzerland;  and

Patrick Shahgaldian, FHNW University of Applied Sciences and Arts Northwestern Switzerland

16.40

Challenges and solutions to receptor occupancy studies by flow cytometry

James Munday, Covance, UK

17.20

New developments in stereodefined RNA therapeutics

Jörg Duschmalé, F Hoffmann-La Roche, Switzerland

18.00

Drinks reception, posters and exhibition

19.00

Conference dinner (optional), at the Keeper's House Restaurant at the Royal Academy of Arts (next door)

 

Tuesday, 22nd May

 

Session 3 - Reactive Metabolites

Session chair:  Toby Athersuch, Imperial College London / DMG

09.30

Mechanistic and translational biomarkers as investigative tools for precision drug-induced liver injury risk assessment
Peter Bradshaw, Imperial College London, UK

10.10

Reactivity of acyl glucuronides
Andrew Stachulski, University of Liverpool, UK

10.50

Towards the development of tests for the prediction of drug immunogenicity

Dean Naisbitt, University of Liverpool, UK

 

Flash poster presentations

11.30

Detection of Bevacizumab in 3D osteosarcoma model using mass spectrometry imaging
Lucy Flint, Sheffield Hallam University, UK (P04)

11.35

Understanding molecular drivers of melanin binding to support rational design of small molecule ophthalmic drugs
Paulina Jakubiak, F Hoffmann-La Roche, Switzerland (P05)

11.40

Time-dependant inhibition demonstrated across multiple classes of uptake transporters
Beáta Kovács, SOLVO Biotechnology, Hungary (P06)

11.45

Changing the drug development paradigm by obtaining quantitative metabolism and disposition data in early clinical studies
Frédéric Lozac’h, Novartis, Switzerland (P08)

11.50

Blood-brain barrier penetration: are in vitro techniques eliminating potential CNS candidates?
Jessie Stow, Astex Therapeutics, UK (P11)

11.55

In vitro metabolite profiling and reaction phenotyping of the dual FLT3/Aurora kinase inhibitor CCT241736 to support selection of preclinical toxicology species and evaluate metabolic pathways in human
Francesca Wood, Institute of Cancer Research, UK (P13)

12.00

Lunch, posters and exhibition

 

 

Session 4 - Medicinal Chemistry and Metabolism

Session chair:  Andrew Stachulski, University of Liverpool / RSC BMCS

13.30

Predicting routes, sites and products of metabolism by Cytochrome P450
Matthew Segall, Optibrium, UK

14.10

Lipophilicity – measurement, prediction and impact

Steve St-Gallay, Sygnature Discovery, UK

14.50

Leveraging humanized animal models to understand human drug disposition

Edna Choo, Genentech, USA

15.30Concluding remarks

15.35

Close

 

Registration, Students and Bursaries
Registration is closed

 

Discounted rates were offered to members of the RSC and the DMDG.  Please view the links below to join either of these bodies. Some student bursaries were also available, and the closing date was 23rd April.   

 

Registration fees:

Early rates for payments received by 14th February
£200  RSC or DMDG member
£300  Non-member
£100  RSC or DMDG student* member
£140  Student* non-member

Standard rates for payments received from 15th February onwards
£300  RSC or DMDG member
£400  Non-member
£150  RSC or DMDG student* member
£200  Student* non-member
 

* Student is an undergraduate or post-graduate, not post-doc.


There was also an optional conference dinner (additional charge) for all on 21st May at the Keeper's House Restaurant (see below).   Delegates were encouraged to book the dinner at the time of registration if required.   The charge for the conference dinner was £60 and places were limited.

 

RSC membership webpage

DMDG membership webpage

 

Exhibition Opportunities
There was the opportunity to sponsor delegate pack inserts at £250 and conference social events. Please contact the secretariat to sponsor this event.  

 

Exhibition opportunities were available for this meeting.  Sorry, fully booked.

 

Exhibition charges:

£750 Exhibition trade stand, including one full delegate – fixed rate
£200 Additional trade stand staff – with no access to technical sessions
These charges excluded the optional conference dinner which should be booked in addition.

 

The exhibition package included:
• Stand space for maximum of two 1 m wide roller panels
• One table measuring 0.8 m deep x 1.6 m wide x 0.725 m high (optional)
• Inclusion of a promotional slide to be played on rotation on the main screen during breaks
• Logo acknowledgement in the delegate handbook

 

Those companies wishing to have a trade stand were encouraged to apply early to avoid disappointment as space is limited. 

 

Cancellation Policy
For cancellations received in writing by the Secretariat, 80% of the fee paid will be refunded for notifications received before 6th May. No refunds will be made for cancellations received from 7th May  onwards, although substitutions are possible at any time. In the unlikely event of our cancelling the event, we will refund the registration fees paid in full.

 

Venue and Travel
The symposium was held at the Royal Society of Chemistry at Burlington House, Piccadilly, London, W1J 0BA, UK. Travel information may be found here.
 

Conference Dinner
The conference dinner was held on the evening of Monday, 21st May, and this could have been booked as an optional extra - charge £60.

 

The dinner was held at the Keeper's House Restaurant at the Royal Academy of Arts, next door to Burlington House, the conference venue.

 

Sponsors
Sponsorship opportunities were available for this meeting, and there were opportunities to sponsor delegate pack inserts and conference social events.

 

We are grateful to EFMC and COMS for supporting this event

 

 

 

 

Organising Committee
Toby Athersuch (chairman), Imperial College London and the DMG
Mark Seymour, Covance and the DMDG
Andrew Stachulski, University of Liverpool and RSC-BMCS
Ian Wilson, Imperial College London and the DMG
 

Secretariat Contact
Maggi Churchouse, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK
Telephone: +44 (0)1359 221004
E-mail:  maggi@maggichurchouseevents.co.uk

 

Registration is closed

 


 

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